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Research Publications
Journal Articles
Lee, R.H. and Mitchell, C.S. (2012). Revisiting the role of spike afterhyperpolarization and spike threshold in motoneuron current-frequency gain. J Neurophysiol (In press, e-pub available on-line).
Mitchell, C.S. and R.H. Lee (2012). Cargo distributions differentiate pathological axonal transport impairments. J Theor Biol 300: 277-291.
Mitchell, C.S. and R.H Lee (2011). Synaptic glutamate spillover increases NMDA receptor reliability at the cerebellar glomerulus. J Theor Biol 289: 217-224. PMID: 21884708
Mitchell, C.S. and R.H Lee (2011). The dynamics of somatic input processing in spinal motoneurons in vivo. J Neurophysiology. 105:1170-1178. PMID: 21191091
Mitchell, C.S. and R.H Lee (2009). A quantitative examination of the role of cargo-exerted forces in axonal transport. J Theor Biol 257(3): 430-7. PMID: 19150364
Mitchell, C.S. and R.H. Lee (2008). Pathology dynamics predict spinal cord injury therapeutic success. J Neurotrauma 25(12): 1483-97. PMID: 19125684
Mitchell, C.S. and R.H. Lee (2007). Output-based comparison of alternative kinetic schemes for the NMDA receptor within a glutamate spillover model. J Neural Eng 4(4): 380-9. PMID: 18057505
Mitchell, C.S., S.S. Feng, and R.H. Lee(2007). An analysis of glutamate spillover on the N-methyl-D-aspartate receptors at the cerebellar glomerulus. J Neural Eng 4(3): 276-82. PMID: 17873430
Books or Book Chapters
Mitchell, C.S. and Lee, R.H. (2012). Dynamic Meta-Analysis as a Therapeutic Prediction Tool for Amyotrophic Lateral Sclerosis. Amyotrophic Lateral Sclerosis. M. H. Maurer. Intech ISBN 979-953-307-199-1
Proceedings
Mitchell, C.S., Glass, J.D. and Lee, R.H. (2012). Identification of prognostic and therapeutic predictors in Amyotrophic Lateral Sclerosis. Society for Neuroscience, New Orleans, LA.
Croft, E., Figanbaum, J., and Mitchell, C.S. (2012) A quantitative assessment of pathophysiological axonal motor-cargo traffic. Society for Neuroscience, New Orleans, LA.
Tilva, K. and Mitchell, C.S. (2012). Dynamic meta-analysis of the G93A SOD1 mouse model predicts the pathology, progression, and treatment responses of ALS, Society for Neuroscience, New Orleans, LA.
R.H. Lee and C.S. Mitchell (2012). Interaction between sodium PICs and motoneuron firing properties. Society for Neuroscience, New Orleans, LA.
R.H. Lee and C.S. Mitchell (2011). Reconceptualization of the motoneuron current-frequency relationship. Society for Neuroscience conference, Washington DC.
Mitchell, C.S. and R.H. Lee (2011). Pathological axonal transport I: Protein aggregation, molecular motor deregulation and mutation. Society for Neuroscience conference, Washington DC.
Orticelli. A.M. and C.S. Mitchell (2011). Pathological axonal transport II: binding cooperativity, ATP, and tau. Society for Neuroscience conference, Washington DC.
Mitchell, C.S. and R.H. Lee (2010). Dynamic Meta-Analysis of the G93A SOD1 mouse model: Pathology dynamics and combination treatment predictions. 21st Annual International Symposium on Amyotrophic Lateral Sclerosis and Motor Neuron Disease, Orlando, FL.
Mitchell, C.S. (2010). ALS Mechanisms, Dynamics, and Treatment: Analytical and Modeling Predictions. International Motoneuron Society conference, Paris, France.
Lee, R.H. and C.S. Mitchell (2010). Role of motoneuron C-terminals in repetitive firing. Society for Neuroscience Conference, San Diego, CA.
Mitchell, C.S. and R.H. Lee (2010). Cargo distributions differentiate motoneuron axonal transport impairment mechanisms in ALS. Society for Neuroscience Conference, San Diego, CA.
Mitchell, C.S. and R.H. Lee (2009). Dynamical predictions of a system–spanning model of ALS and its response to hypothetical treatments. Society for Neuroscience conference, Chicago, I
Lee, R.H. and C.S. Mitchell (2009). Relational Analysis of Motoneuron Firing Properties. Society for Neuroscience conference, Chicago, IL.
Mitchell, C.S., C.M. Simon, M.C. LaPlaca, R.H. Lee (2009). A Comprehensive Approach to Understanding Spinal Cord Injury, Christopher Reeves Foundation Symposium, Atlanta, GA,
Mitchell, C.S. and R.H. Lee (2008). Comprehensive examination of secondary spinal cord injury and potential single and combinatorial neuroprotective therapeutic strategies , 26th Annual National Neurotrauma Symposium, Orlando, FL.
Mitchell, C.S. and R.H. Lee (2008). A Re-examination of the AHP: Is it diffusion limited?, 2008 Mechanisms of Plasticity and Disease in Motoneurons, Seattle, WA.
Mitchell, C.S. and R.H. Lee (2008). A quantitative assessment of secondary injury dynamics and potential multi-faceted neuroprotective therapeutics. Society for Neuroscience, Washington DC
Mitchell C.S. and R.H. Lee (2008). A Reconceptualization of the relationship between spike afterhypolarization and firing rate in lumbar motoneurons of the adult cat. Society for Neuroscience, Washington DC
Mitchell, C.S. and R.H. Lee (2007). Comparison of degenerate NMDA-receptor models in the context of a larger model. Society for Neuroscience, San Diego, CA.
Mitchell, C.S. and R.H. Lee (2007). A computational model of secondary traumatic injury. Society for Neuroscience, San Diego, CA
Mitchell, C.S. and R.H. Lee (2007). Biological Model Analysis: What does complexity theory have to offer? Integrative Systems Biology Symposium, Georgia Institute of Technology, Atlanta, GA.